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Medication Safety

Medication safety interest group

posted Nov 24, 2009, 1:15 AM by 藥物教育資源中心DERC

(Originally posted on 2005-05-22)

At the first GC meeting, we have decided to formally form a Medication Safety Interest Group. We hope that this group could meet regularly, each one bringing significant issues to the group for sharing and discussion, problem identification and eventually formulating actions to propose to the authorities, drug companies and our staff.

3 GC members are responsible for leading this group: Mr Michael Ling, Ms Cecilia Choi, and Ms Winnie Cheng.

We will soon call our first meeting and hope you would prepare and join us in this important and meaning mission. Hot topics such as drug allergy, similar drug name/appearance, proper ways of checking or any other issues could be tabled for discussion. Do watch out for our further announcement.

Zanidip misprints dosage instruction

posted Nov 24, 2009, 1:14 AM by 藥物教育資源中心DERC

(Originally posted on 2004-10-01)

On the outer box of Zanidip (Lercanidipine) tablet, the instruction reads "1 tablet after breakfast" in both English and Chinese.

But in the package insert of this calcium channel blocker, it states that Zanidip "should be taken before meals."

We have confirmed with the supplier, Schwarz Pharma, that the drug should be taken before meals. They have put on correctional stickers to amend the wordings on the box.

In fact, the absolute bioavailability of Lercanidipine is about 10% because of high first pass metabolism. The bioavailability increases 4-fold when it is ingested up to 2 hours after a high fat meal, and about 2-fold when taken immediately after a carbohydrate-rich meal. Consequently, Lercanidipine should be taken at least 15 minutes before a meal.

Dosage confusion with Cravit

posted Nov 24, 2009, 1:12 AM by 藥物教育資源中心DERC   [ updated Nov 24, 2009, 1:13 AM ]

(Originally posted on 2004-10-01)

Cravit used to be marketed in 100mg tablet. Then the 250mg tablet became available. However the dosage recommendations for the two strengths are quite different.

For the 100mg packing, the dosage recommendation ranges from 100mg to 200mg, given 2 to 3 times a day, depending on the types of infection.

However, the dosage recommendation for Cravit 250mg is based on a single daily dose regimen. Details may be obtained from the attached document (PDF).

According to the supplier Daiichi Pharmaceutical, the dosage of the 250mg tablet packing is the latest recommendation.

Spiriva (Tiotropium) capsules for inhalation

posted Nov 24, 2009, 1:07 AM by 藥物教育資源中心DERC   [ updated Nov 24, 2009, 1:12 AM ]

(Originally posted on 2004-07-23)

A member reported to us a potential risk concerning Spiriva capsule for inhalation.

Spiriva (Tiotropium) comes in a strip packed capsules to be used for inhalation with the HandiHaler device.

The outer packing indicate, in small prints, that the capsule is to be used "Only for inhalation with HandiHaler device".

The wordings of "Not to be swallowed" are printed in both English and Chinese.

But when the capsules are dispensed without the package, there is no similar warning on the strip pack:

Thus, there is a potential risk of a patient swallowing the capsules by mistake.

SHPHK will feedback to the manufacturer about the problem. In the mean time, pharmacist's counselling to patients would be an essential step in protecting the patient.

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