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Clinically important drug interactions

posted Nov 24, 2009, 12:33 AM by DERC 藥物教育資源中心

(Originally posted on 2004-06-13)

Significant drugs interactions commonly encountered (and worth notifying the prescriber):

  1. Phenytoin
    • Blood level changed by some antibiotics, esp. ofloxacin
  2. Quinolones
    • Increases warfarin effects
    • Increases theophylline concentration in blood
  3. Thyroxine
    • Increases warfarin effect
Absorption interactions commonly seen (and worth prompting the nursing staff and patients to space out the time of administration):
  1. Antacids
    • ACEIs
    • Antibiotics: quinolones, INAH, rifampicin, tetracyclines, gabapentin,
    • phenytoin etc.
    • Antifungals: the *conazoles
    • Digoxin
  2. Cholestyramine
    • Esp. anticoagulants
  3. Iron (incl. Fortifer)
    • Magnesium Trisilicate
    • Tetracyclines and quinolones
    • Penicillamine
    • Zinc
  4. Kaolin
    • Antibiotics
    • Antiarrhythmics
    • Digoxin
  5. Sucralfate:
    • Anticoagulants
    • Antiepileptics
    • Digoxin
    • Quinolones
    • Thyroxine
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