(Originally posted on 2004-06-13)

Test dose: Adult: 5000 units in 0.1ml; Children: 1000 units in 0.1ml

Method: Intradermal injection

Material: Penicillin G 600mg/vial (1,000,000u/vial)

Dilution method: Assume the change in volume due to dissolution of powder is negligible after dilution.

Adult: Method A

1. Pen G 1 vial + 2ml water for injection = 1,000,000u/2ml
2. 0.1ml (50,000u) of (i) + 0.9ml water for inj. = 5,000u/0.1ml

Adult: Method B

1. Pen G 1 vial + 4ml water for injection = 1,000,000u/4ml
2. 0.1ml (25,000u) of (i) + 0.4ml water for inj. = 5,000u/0.1ml

Children:

• 5,000u (0.1ml) Pen G in (Method A or B) + 0.4ml water for injection = 1,000u/0.1ml

Reference: Drug Information Handbook 6th ed. 1998-1999, Lexi-Comp. Inc.